Human tyrosinase (hTyr) is a Type 1 membrane bound glycoenzyme that catalyzes the initial and rate-limiting steps of melanin production in the melanosome.Mutations in the Tyr gene are linked to oculocutaneous albinism type 1 (OCA1), an autosomal recessive disorder.Currently, the application of enzyme replacement therapy for a treatment of OCA1 is h
This study investigates the use of a CuBr vapor nanosecond laser with a 510 nm/578.2 nm wavelength for the surface treatment of 1050 aluminum and 2219 aluminum alloys.Laser-induced periodic surface structuring was used to optimize processing parameters to achieve hydrophobic and hydrophilic properties on the surface.The wetting properties were meas
Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine.Thus, in the present study, collagen cationic CPs were simply separated using ion-exchange resin from bovine CPs, to modify mixed nanomicelles (MMs) on the surface to improve the oral bioavailabili
Background Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are Personal Lubricants currently used to treat patients with diabetes.Previous studies have demonstrated that treatment with SGLT-2 inhibitors is accompanied by altered metabolic phenotypes.However, it has not been investigated whether the hypothalamic circuit participates in the develo
KD Construction is a new company in the construction industry, it was opened by Mr.Irfan and Mr.Kamran on February 6, 2013.The company constructs houses for individuals and for builders, commercial shopping malls and also works as a subcontractor for big construction companies like Habib, Paragon and AMCE Private Limited.KD worked on only small pro